Question #44231

Compound A, 2-($\beta$-D-glucopyranosyloxy)pyridine, undergoes enzymatic hydrolysis in an aqueous medium at $300\text{ K}$ to yield D-glucose and 2-hydroxypyridine. The released 2-hydroxypyridine subsequently undergoes complete tautomerization to its more stable keto form, 2-pyridone.\n\nGiven the following thermodynamic data at $300\text{ K}$:\n\nStandard enthalpy of combustion ($\Delta H^\circ_c$) in $\text{kJ/mol}$:\nCompound A (s) = $-4500$\nD-Glucose (s) = $-2800$\n2-Hydroxypyridine (s, enol form) = $-1715$\n\nStandard enthalpy of solution ($\Delta H^\circ_{sol}$) in $\text{kJ/mol}$:\nCompound A (s) = $+30$\nD-Glucose (s) = $+12$\n2-Hydroxypyridine (s, enol form) = $+8$\n\nThermodynamic parameters for the tautomerization $\ce{2-Hydroxypyridine (aq) <=> 2-Pyridone (aq)}$:\n$\Delta G^\circ_{taut} = -25.0\text{ kJ/mol}$\n$\Delta S^\circ_{taut} = -30.0\text{ J K}^{-1}\text{mol}^{-1}$\n\nCalculate the standard observed enthalpy of the overall reaction ($\Delta H^\circ_{obs}$) for the hydrolysis of Compound A (aq) yielding D-glucose (aq) and 2-pyridone (aq) at $300\text{ K}$.