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Question #47693
The Question
A patient who underwent a renal transplant is maintained on a bioactive molecule produced by the fungus Trichoderma polysporum. Years later, the patient develops a rapidly metastasizing tumor. Which of the following statements correctly identifies the prescribed drug and the physiological basis for this accelerated oncogenic escape?
Options
- A.
Statins; they competitively inhibit cholesterol synthesis, thereby weakening the plasma membrane of natural killer cells.
- B.
Cyclosporin A; it suppresses cell-mediated immunity, thereby impairing the T-lymphocyte surveillance required to detect and destroy neoplastic cells.
- C.
Cyclosporin A; it suppresses humoral immunity by inhibiting B-lymphocyte proliferation, reducing the antibody-mediated opsonization of cancer cells.
- D.
Streptokinase; it acts as a clot-buster, inadvertently dissolving the fibrin mesh around the primary tumor and facilitating metastasis.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Cyclosporin A Immunomodulation|MALT Structure|Cell-mediated Immunity
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students must integrate facts from two different NCERT chapters ('Microbes in Human Welfare' and 'Human Health and Disease').
The core misconception tested is the specific arm of the immune system targeted by Cyclosporin A and responsible for tumor surveillance.
Students often memorize 'immunosuppressant' without distinguishing between Cell-Mediated Immunity (T-cells, responsible for graft rejection and cancer surveillance) and Humoral Immunity (B-cells).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Microbes in Human Welfare - Class 12 |
| Concept | Cyclosporin A Immunomodulation |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |