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Question #47663
The Question
HIV relies heavily on the host macrophage's cytosolic ATP pool to fuel energy-intensive processes, such as the phosphorylation of nucleotides required for reverse transcription. If a competitive inhibitor specifically blocks the enzyme responsible for the FIRST Substrate Level Phosphorylation (SLP) in the host's glycolytic pathway, which of the following accurately represents the blocked metabolic step and its immediate consequence on the viral life cycle?
Options
- A.
Conversion of Phosphoenolpyruvate to Pyruvic acid; failure of the viral DNA to integrate into the host genome.
- B.
Conversion of 1,3-bisphosphoglyceric acid to 3-phosphoglyceric acid; stalling of viral DNA synthesis by reverse transcriptase.
- C.
Conversion of Fructose-6-phosphate to Fructose-1,6-bisphosphate; inhibition of viral assembly at the host plasma membrane.
- D.
Conversion of 3-phosphoglyceric acid to 2-phosphoglycerate; inability of the viral envelope to bind to the CD4 receptor.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Glycolysis|HIV Reverse Transcription|ATP-dependent assembly
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Integrating Class 11 Respiration (Glycolysis SLP sites) with Class 12 Human Health and Disease (HIV replication cycle).
Students often memorize these pathways in isolation.
The trap tests the exact sequence of ATP-yielding steps in glycolysis and applies it to the spatial and energetic requirements of the HIV life cycle, specifically targeting the cytosolic dependency of reverse transcriptase.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Respiration in Plants - Class 11 |
| Concept | Substrate Level Phosphorylation (SLP) Sites |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |