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Question #47479
The Question
A specific genetic mutation results in the truncation of a membrane-bound G-protein coupled receptor (GPCR) on the surface of human macrophages and Helper T-cells. Normally, this receptor binds to peptide signaling molecules to regulate immune responses. Which of the following dual physiological and clinical consequences is most likely observed in an individual homozygous for this mutation?
Options
- A.
Failure to generate secondary messengers in response to specific chemokines, accompanied by innate resistance to HIV-1 entry.
- B.
Direct entry of peptide signaling molecules into the cytoplasm, leading to accelerated integration of the HIV provirus.
- C.
Loss of intracellular receptors for steroid hormones, resulting in the inability of HIV to utilize the host's reverse transcriptase.
- D.
Continuous activation of the membrane-bound receptor, causing overproduction of cAMP and rapid depletion of CD4+ T-cells.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
G-Protein_Coupled_Receptors|CCR5_Receptor|HIV_Entry
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Integrating the Endocrine principle of 'Membrane-Bound Receptors & Secondary Messengers' with the Human Health principle of 'Viral Entry Mechanisms'.
The core trap lies in conflating the mechanism of peptide hormones (which stay outside and use secondary messengers) with steroid hormones (which go inside), while simultaneously testing the NCERT-Plus knowledge that viruses like HIV physically hijack normal physiological signaling receptors as structural entry portals.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Chemical Coordination and Integration - Class 11 |
| Concept | Hormone Receptors Location |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |