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Question #47474
The Question
During the acquisition of a complex motor skill, synaptic plasticity in the cerebellum relies heavily on intracellular signaling. If a specific neurotoxin inhibits the G-protein coupled receptors (GPCRs) responsible for generating Inositol trisphosphate (IP3) in the post-synaptic Purkinje cells, which of the following is the most likely physiological consequence?
Options
- A.
Impaired acquisition of precise voluntary movements due to the failure of IP3-mediated intracellular calcium release, disrupting post-synaptic metabolic modulation.
- B.
Complete blockage of pre-synaptic neurotransmitter exocytosis due to the inability of IP3 to open voltage-gated calcium channels on the axonal terminal.
- C.
Immediate paralysis of skeletal muscles because the primary motor cortex relies exclusively on IP3 cascades for generating efferent electrical impulses.
- D.
Loss of involuntary autonomic reflexes due to the disruption of cAMP-dependent kinase activity in the cerebellar white matter.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Cerebellum|Purkinje Cells|Hormone Receptors|Neurotransmitters
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often compartmentalize NCERT chapters, assuming neural transmission is strictly electrical (ionotropic) and secondary messengers (IP3, cAMP) are exclusively for endocrine hormones.
The trap exploits the failure to recognize that post-synaptic integration involves metabolic cascades crucial for synaptic plasticity.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Neural Control and Coordination - Class 11 |
| Concept | Cerebellar Coordination Dynamics |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |