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Question #47470
The Question
A male athlete chronically self-administers high doses of exogenous anabolic steroids. Based on the principles of the Hypothalamic-Pituitary-Gonadal (HPG) axis, which of the following physiological changes is LEAST likely to occur as a direct consequence?
Options
- A.
Suppression of GnRH release into the hypophyseal portal circulation via enhanced negative feedback.
- B.
Atrophy of the testes and a significant decline in spermatogenesis due to reduced FSH stimulation of Sertoli cells.
- C.
Hypertrophy of the interstitial cells of Leydig to compensate for the systemic increase in circulating androgens.
- D.
A marked reduction in the secretion of Luteinizing Hormone (LH) from the pars distalis.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Neurotransmitter Receptor Specificity|Hypothalamic-Pituitary Axis Integration|Hormonal Feedback Loops
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often assume that high levels of a hormone might cause its source gland to undergo 'compensatory hypertrophy'.
However, they fail to recognize that glandular maintenance is strictly dependent on anterior pituitary trophic hormones (like LH).
High exogenous steroids suppress LH via negative feedback, inevitably leading to Leydig cell and testicular atrophy.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Neural Control and Coordination - Class 11 |
| Concept | Neurotransmitter Receptor Specificity |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |