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Question #47403
The Question
Rheumatoid arthritis is a chronic disorder that severely restricts the movement of synovial joints, such as hinge joints. Which of the following statements accurately describes its primary pathophysiological mechanism and distinguishes it from other joint disorders?
Options
- A.
It initiates with the immunological destruction of the synovial membrane, leading to the formation of a granulation tissue called pannus, which subsequently erodes the articular cartilage.
- B.
It is primarily a degenerative disease characterized by the mechanical wear and tear of the articular cartilage, followed by a secondary depletion of synovial fluid.
- C.
It is characterized by the deposition of uric acid crystals within the synovial cavity, which directly triggers an autoimmune destruction of the synovial membrane.
- D.
It involves the direct autoimmune destruction of the articular cartilage by cytotoxic T-cells, leaving the synovial membrane and lubricating fluid initially intact.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Synovial_Joint_Varieties|Autoimmunity_Principles|Rheumatoid_Arthritis
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Distinguishing between mechanical joint degradation (Osteoarthritis) and systemic immunological synovial membrane destruction (Rheumatoid arthritis).
A common misconception is that all forms of arthritis begin with direct cartilage destruction.
In RA, the primary event is synovial inflammation, and cartilage destruction is a secondary consequence of 'pannus' formation.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Locomotion and Movement - Class 11 |
| Concept | Synovial Joint Varieties |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |