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Question #47386
The Question
A 40-year-old patient exhibits severe anemia despite hypersecretion of erythropoietin (EPO) from the juxtaglomerular cells. Radiological studies reveal a systemic pathology that has severely calcified and reduced the medullary cavity spaces of exactly 80 bones in the body. Which of the following statements correctly correlates the anatomical defect with the physiological failure?
Options
- A.
The appendicular skeleton has lost its red bone marrow, preventing EPO from stimulating the maturation of proerythroblasts.
- B.
The axial skeleton's hematopoietic microenvironment is compromised, rendering the EPO-mediated feedback loop ineffective.
- C.
The calcification of the 80 bones of the appendicular skeleton has blocked the release of iron required for hemoglobin synthesis.
- D.
The pathology has destroyed the yellow bone marrow in the axial skeleton, which is the primary site of adult erythropoiesis.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
Erythropoietin Function|Axial Skeleton Count|Bone Marrow
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often memorize that 'bone marrow produces blood cells' but fail to distinguish between the functional roles of the axial (80 bones, red marrow) vs. appendicular skeleton (126 bones, yellow marrow) in adults.
This question tests the integration of skeletal anatomy (number and type of bones) with endocrine regulation (EPO targeting specific hematopoietic niches).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Locomotion and Movement - Class 11 |
| Concept | Axial Skeleton Count |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |