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Question #46786
The Question
A genetic mutation causes the misfolding of the extracellular binding domain of receptors on the anterior pituitary gonadotrophs, completely preventing the binding of the hypothalamic hormone GnRH. Which of the following correctly identifies the disrupted cellular mechanism and the subsequent hormonal profile in a post-pubertal female?
Options
- A.
Failure to generate secondary messengers (e.g., IP3, Ca2+); resulting in elevated GnRH, decreased FSH/LH, and decreased estrogen.
- B.
Failure of the hormone-receptor complex to regulate gene expression directly; resulting in elevated GnRH, decreased FSH/LH, and decreased estrogen.
- C.
Failure to generate secondary messengers; resulting in decreased GnRH, elevated FSH/LH, and decreased estrogen.
- D.
Failure of the hormone to diffuse through the lipid bilayer; resulting in elevated GnRH, elevated FSH/LH, and decreased estrogen.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
Glandular Secretion Mechanism|Secondary Messenger Cascade|Progesterone/Estrogen Feedback
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Integrating the biochemical mechanism of hormone action (peptide vs. steroid) with the systemic physiological feedback loops of the Hypothalamus-Pituitary-Ovarian (H-P-O) axis.
Students often fail to connect molecular receptor dynamics (secondary messengers) with macro-level clinical profiles (loss of negative feedback causing elevated upstream hormones).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Biomolecules - Class 11 |
| Concept | Peptide Bond Geometry |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |