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Question #46777
The Question
Hepatocytes residing in the quiescent stage ( phase) are stimulated by growth factors to re-enter the cell cycle. During the subsequent division, a specific inhibitor prevents the decatenation (untangling) of DNA at the centromeres, leaving the sister chromatids physically interlocked. Which of the following represents the most likely immediate consequence during the M-phase?
Options
- A.
Activation of the Spindle Assembly Checkpoint, preventing the activation of the Anaphase Promoting Complex (APC).
- B.
Arrest of the cell cycle at the /M checkpoint due to the detection of incomplete DNA replication.
- C.
Failure of homologous chromosomes to separate during anaphase, directly resulting in aneuploidy.
- D.
Unrestricted progression into telophase, resulting in a binucleate cell due to cytokinesis failure.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
Centromere Positionality|G0 Phase Quiescence|Meiotic Reductional Division
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Distinguishing the specific roles of cell cycle checkpoints and the exact mechanics of mitosis.
The primary trap (Option C) relies on the student confusing 'sister chromatids' with 'homologous chromosomes'—a high-frequency NEET error.
Furthermore, it tests the NCERT-Plus application of the Anaphase Promoting Complex (APC), requiring students to link structural chromosome issues (catenation) to biochemical checkpoint activation (SAC/APC).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Cell – The Unit of Life - Class 11 |
| Concept | Centromere Positionality |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |