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Question #46775
The Question
A female individual possesses a chromosomal translocation that significantly shifts the position of the centromere on a specific autosome. During the resumption of meiosis in her tertiary ovarian follicles, this structural alteration is most likely to cause aneuploidy through which of the following mechanisms?
Options
- A.
Disruption of bipolar spindle tension at the kinetochores during Metaphase I, leading to the non-disjunction of homologous chromosomes.
- B.
Premature splitting of the altered centromere during Anaphase I, resulting in the unequal segregation of sister chromatids.
- C.
Failure of chiasmata terminalization during Diakinesis, permanently arresting the primary oocyte in Prophase I.
- D.
Inability of the secondary oocyte to align at the metaphase plate, causing non-disjunction during Meiosis II after fertilization.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Centromere Positionality|Meiotic Reductional Division|Meiotic Arrest Points
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: The question tests the synthesis of Cell Division mechanics and Genetic disorders.
The primary trap is Option B, which exploits the common misconception that centromeres split during Anaphase I.
Students must recall the exact NCERT line: 'homologous chromosomes separate, while sister chromatids remain associated at their centromeres' during Anaphase I, and link centromere position to spindle tension (SAC) during Metaphase I alignment.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Cell – The Unit of Life - Class 11 |
| Concept | Centromere Positionality |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |