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Question #46766
The Question
A novel metabolic inhibitor specifically targets and blocks the ATPase activity of the protein forming the side arms of the 'A' tubules in the 9+2 axonemal structure of human cells. If this inhibitor is introduced into the respiratory tract, which of the following physiological imbalances is most likely to occur?
Options
- A.
Paralysis of the mucociliary escalator, leading to mucus plugging and a subsequent increase in physiological dead space.
- B.
Inability of alveolar macrophages to perform amoeboid movement, leading to severe respiratory infections.
- C.
Failure of the epiglottis to close during swallowing, causing aspiration of particulate matter into the trachea.
- D.
Spastic constriction of the bronchiolar smooth muscles, directly reducing the anatomical dead space volume.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Cilia and Flagella Ultrastructure|Dead Space Ventilation|Breathing and Exchange of Gases
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Integrating cell biology (9+2 ciliary ultrastructure and dynein ATPase) with gross respiratory physiology (mucociliary clearance and dead space).
Students often fail to connect molecular motor inhibition to macroscopic ventilation-perfusion imbalances.
The trap lies in confusing the cytoskeletal elements responsible for different movements (e.g., actin/myosin in macrophages and smooth muscles vs. tubulin/dynein in cilia).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Cell – The Unit of Life - Class 11 |
| Concept | Cilia and Flagella Ultrastructure |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |