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Question #46747
The Question
A researcher treats a eukaryotic cell with a chemical inhibitor that specifically blocks the transfer of electrons to oxygen at Complex IV of the mitochondrial electron transport chain. While the primary effect is the cessation of oxidative phosphorylation, this also profoundly impacts the endomembrane system. Which of the following statements correctly describes the most direct downstream effect on lysosomal homeostasis?
Options
- A.
The lysosomal pH will increase towards neutrality due to the failure of primary active proton transport, rendering acid hydrolases inactive.
- B.
The lysosomal V-ATPases will reverse their function and utilize the cytosolic proton accumulation to synthesize ATP, maintaining the acidic lumen.
- C.
The lysosomal membrane will hyperpolarize as protons passively diffuse into the lumen to compensate for the lack of metabolic water.
- D.
The lysosomal pH will decrease further as anaerobic glycolysis produces excess lactic acid, hyperactivating the hydrolytic enzymes.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Terminal_Electron_Acceptor|V-type_H+-ATPase|Metabolic_Water_Formation
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Organelle interdependence and the thermodynamics of active transport.
Students often memorize 'lysosomes are acidic' but fail to connect that this state is a non-equilibrium condition actively maintained by ATP derived from mitochondria.
The primary trap (Option D) exploits the misconception that general cellular acidosis (from anaerobic glycolysis) would make lysosomes more acidic, ignoring the failure of the primary active transport mechanism.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Cell – The Unit of Life - Class 11 |
| Concept | Lysosomal pH Homeostasis |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |