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Question #46743
The Question
In a mutant multipolar neuron, the spatial polarity of the Golgi apparatus is inverted relative to the cytoskeleton. While neurotransmitter synthesis and post-synaptic receptor specificity remain completely normal, synaptic transmission fails. Based on the principles of cellular trafficking and neural coordination, which of the following best explains this functional disconnect?
Options
- A.
Synaptic vesicles are misdirected to the dendritic membrane, resulting in neurotransmitter release away from the synaptic cleft.
- B.
Sorting of vesicles at the cis face is disrupted, causing neurotransmitters to be packaged into lysosomes for degradation.
- C.
The post-synaptic receptors fail to recognize the neurotransmitters due to defective glycosylation in the inverted Golgi.
- D.
Vesicles reach the axon terminal but fail to undergo exocytosis due to the absence of calcium-dependent fusion proteins.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Evolutionary_Exception
Tackle problems where standard rules evolve or change based on specific environmental constraints.
Concepts Behind This Question
Golgi Polarity|Neurotransmitter Receptor Specificity|Synaptic Transmission
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often memorize that the Golgi apparatus 'packages materials' but fail to connect its structural polarity (cis vs trans faces) to spatial cellular functions, such as directed axonal transport.
The trap lies in assuming synaptic failure must be due to receptor defects (Option C) or terminal exocytosis failure (Option D), ignoring the upstream topological sorting at the trans Golgi network.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Cell – The Unit of Life - Class 11 |
| Concept | Golgi Polarity |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |