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Question #46742
The Question
A rare genetic mutation disrupts the structural integrity of the Golgi matrix in hepatocytes, resulting in the complete loss of its distinct cis (forming) and trans (maturing) spatial segregation. Assuming the rough endoplasmic reticulum (RER) continues to function normally, which of the following physiological consequences is most likely to occur?
Options
- A.
Systemic edema due to a reduction in blood colloid osmotic pressure caused by the rapid degradation of hypoglycosylated albumins.
- B.
Complete cessation of albumin synthesis, leading to a drastic drop in both hydrostatic and oncotic pressures in the capillaries.
- C.
Accumulation of misfolded plasma proteins in the RER lumen, triggering immediate hepatocyte apoptosis.
- D.
Increased retention of tissue fluid in the blood vessels due to the hyper-secretion of unmodified globulins.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Golgi Polarity|Plasma Proteins and Osmotic Pressure
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: This question tests the integration of Cell Biology (Golgi function) with Human Physiology (Body Fluids and Circulation).
Students often compartmentalize these units.
The trap lies in confusing the site of protein synthesis/folding (RER) with the site of post-translational modification (Golgi).
A common misconception is assuming that a Golgi mutation halts protein synthesis entirely, rather than specifically altering the protein's functional half-life and subsequent osmotic properties.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Cell – The Unit of Life - Class 11 |
| Concept | Golgi Polarity |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |