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Question #46734
The Question
The endomembrane system functions through highly coordinated vesicular transport. Brefeldin A is a chemical inhibitor that blocks anterograde transport, causing the Golgi apparatus to collapse back into the Endoplasmic Reticulum (ER). If an actively secreting mammalian cell is treated with Brefeldin A, which of the following statements represents an INCORRECT consequence?
Options
- A.
The formation of primary lysosomes is completely arrested due to the lack of packaging at the trans-Golgi network.
- B.
The continuous renewal of the plasma membrane is halted, disrupting the turnover of integral membrane proteins.
- C.
The translation of secretory proteins by ribosomes on the Rough ER is immediately arrested to prevent luminal toxicity.
- D.
Secretory proteins fail to undergo final modification into glycoproteins, accumulating in the ER and triggering the Unfolded Protein Response (UPR).
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
RER|Golgi_Apparatus|Vesicular_Transport
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: The 'Instantaneous Feedback' misconception.
Students often erroneously assume that blocking a downstream organelle (Golgi) immediately shuts down the upstream organelle (Rough ER).
In reality, biological systems often continue upstream synthesis until physical accumulation triggers a distinct stress pathway (like the UPR).
This deeply tests the NCERT concept of endomembrane coordination by asking how the coordination fails under chemical inhibition.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Cell – The Unit of Life - Class 11 |
| Concept | Endomembrane System Connectivity |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |