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Question #46723
The Question
A researcher isolates a mutant strain of human plasma cells from the Mucosa-Associated Lymphoid Tissue (MALT). These cells exhibit a severe defect in the -dependent association of their ribosomal subunits. Which of the following represents the most accurate physiological fallout of this cellular dysfunction?
Options
- A.
Severe mucosal immunodeficiency due to the inability of 80S ribosomes on the Rough ER to translate the heavy and light chains of secretory IgA.
- B.
Failure in the primary immune response due to the dysfunction of 70S ribosomes in the cytoplasm, halting the synthesis of IgM pentamers.
- C.
Accumulation of unprocessed heterogeneous nuclear RNA (hnRNA) in the nucleus, preventing the formation of the antibody complex.
- D.
Impaired cell-mediated immunity in the mucosal lining due to the inability of the Golgi apparatus to glycosylate T-cell receptors.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Ribosome Svedberg Coefficient|MALT Structure|Secretory_IgA_Synthesis
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Integrating Molecular Biology (Translation machinery) with Human Health (MALT function).
Students often fail to connect that antibodies are secretory proteins synthesized by 80S ribosomes on the RER.
The primary trap is Option B, which tests the quantitative nuance of eukaryotic (80S) vs prokaryotic (70S) ribosomes, and Option C, which confuses translational failure with transcriptional/post-transcriptional control.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Cell – The Unit of Life - Class 11 |
| Concept | Ribosome Svedberg Coefficient |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |