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Question #46559
The Question
Chronic substance abuse induces long-term neuroadaptation in the brain's reward circuit, leading to dependence. Upon sudden cessation of the drug, the individual experiences severe withdrawal syndrome. Based on the principles of molecular inheritance and epigenetics, which of the following molecular events best explains the physiological manifestations of this withdrawal?
Options
- A.
Immediate translation of highly repetitive satellite DNA sequences into withdrawal-specific neurotoxic proteins.
- B.
Reactivation of dormant transcriptional pathways due to altered histone acetylation and chromatin remodeling near regulatory repetitive DNA.
- C.
Permanent deletion of structural genes coding for neurotransmitter receptors due to drug-induced frameshift mutations.
- D.
Complete transcriptional silencing of the reward pathway genes due to sudden hypermethylation of euchromatin.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Human_Genome_Repetitive_DNA|Chromatin_Remodeling|Transcription_Factors
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often view drug withdrawal purely as a neurotransmitter deficit (chemical void) rather than a molecular/epigenetic event involving transcriptional drift.
Furthermore, a common misconception is treating repetitive DNA as purely 'junk' or structural (centromeres/telomeres), missing its regulatory role in chromatin dynamics as highlighted in the Human Genome Project findings.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Human Health and Disease - Class 12 |
| Concept | Drug Withdrawal Syndrome |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |