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Question #46553
The Question
A patient is prescribed a bioactive molecule extracted from the yeast Monascus purpureus to manage a cardiovascular condition. Researchers observe that prolonged use of this agent subtly impairs the signal transduction of cannabinoid receptors in the brain. Based on the fluid mosaic model and receptor biochemistry, which of the following best explains this phenomenon?
Options
- A.
The agent competitively inhibits HMG-CoA reductase, reducing membrane cholesterol and destabilizing lipid rafts required for optimal G-protein coupled receptor signaling.
- B.
The agent acts as a structural analogue of cannabinoids, competitively binding to the receptors and preventing the attachment of natural ligands.
- C.
The reduction in cholesterol increases the overall rigidity of the plasma membrane, directly preventing the endocytosis of the cannabinoid-receptor complex.
- D.
The agent directly denatures the transmembrane domains of the cannabinoid receptors by altering the hydrophilic interactions in the extracellular matrix.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Cannabinoids|Statin Mechanism of Action|Lipid Rafts
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: This question requires the integration of three distinct NCERT concepts: Statins as cholesterol-lowering agents (Microbes in Human Welfare), the role of cholesterol in the fluid mosaic model (Cell: The Unit of Life), and receptor-mediated signaling (Chemical Coordination/Human Health).
The common misconception is treating statins purely as systemic cardiovascular drugs without recognizing their fundamental cellular impact on membrane lipid composition and downstream receptor functionality.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Human Health and Disease - Class 12 |
| Concept | Opioids/Cannabinoids/Coca Alkaloids |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |