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Question #46550
The Question
The progression of HIV infection into AIDS is marked by a severe collapse of the immune system, often accompanied by opportunistic malignancies like Kaposi's sarcoma that rapidly metastasize. Regarding the relationship between HIV pathogenesis and this oncogenesis, which of the following statements is INCORRECT?
Options
- A.
The profound decline in CD4+ Helper T-cells compromises Cell-Mediated Immunity (CMI), leading to a failure in immune surveillance against nascent tumor cells.
- B.
HIV acts as a direct oncogenic virus by inserting its proviral DNA into the host's tumor suppressor genes, directly initiating Kaposi's sarcoma.
- C.
The concurrent failure of T-cell mediated immunoediting allows metastatic cells to evade destruction and establish secondary tumors.
- D.
Macrophages continue to act as an 'HIV factory' while the depletion of Helper T-cells impairs the activation of cytotoxic T-lymphocytes required for tumor clearance.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Retroviridae|Helper_T_Cells|Malignancy
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Distinguishing between 'direct viral oncogenesis' (where a virus directly mutates host DNA) and 'indirect viral oncogenesis' (where a virus destroys the immune system's tumor surveillance capabilities).
Students often falsely assume that because HIV is a retrovirus, it directly initiates cancer via insertional mutagenesis, ignoring the NCERT emphasis on opportunistic infections arising strictly from Helper T-cell depletion.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Human Health and Disease - Class 12 |
| Concept | Metastasis |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |