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Question #46522
The Question
A patient who recently underwent a kidney transplant is prescribed Cyclosporin A as an immunosuppressive agent. If this patient is exposed to a severe allergen, they can still experience an acute anaphylactic shock. Which of the following best explains this clinical observation?
Options
- A.
Cyclosporin A suppresses cell-mediated immunity by inhibiting T-cell activation, but acute allergy is an immediate response driven by pre-existing IgE-bound mast cells.
- B.
Cyclosporin A selectively inhibits B-lymphocytes to prevent graft rejection, whereas acute allergic reactions are exclusively mediated by cytotoxic T-lymphocytes.
- C.
The drug neutralizes circulating histamine and serotonin but fails to prevent the rapid synthesis of new IgE antibodies during anaphylaxis.
- D.
Anaphylaxis is a delayed hypersensitivity reaction that relies on memory T-cells, which are inherently resistant to the effects of Cyclosporin A.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Mast_Cells|Histamine|Cyclosporin_A|T-lymphocytes
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often overgeneralize the term 'immunosuppressant', assuming a drug like Cyclosporin A dampens the entire immune system equally.
The trap lies in failing to distinguish between the specific cellular targets of graft rejection (T-cells/Cell-mediated immunity) and acute allergies (IgE/Mast cells/Immediate hypersensitivity).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Human Health and Disease - Class 12 |
| Concept | Allergy Mechanism |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |