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Question #46511
The Question
Autoimmune diseases such as Rheumatoid arthritis exhibit chronic, progressive tissue destruction. Based on the principles of acquired immunity, which of the following best explains the sustained and highly intensified nature of this auto-reactive tissue damage?
Options
- A.
Continuous triggering of a primary immune response mediated predominantly by low-affinity IgM antibodies against self-antigens.
- B.
The generation of memory cells against self-antigens, resulting in a continuous, high-intensity secondary (anamnestic) response.
- C.
Hypertrophy of the thymus gland in adults, leading to the continuous release of auto-reactive T-lymphocytes that evade clonal deletion.
- D.
The complete suppression of the innate immune system, forcing the acquired immune system to overreact to self-tissues.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Self-Tolerance|Memory cells|B-cell hyper-responsiveness
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often view autoimmunity merely as 'the body attacking itself' without applying the specific mechanics of acquired immunity (primary vs. secondary responses) to the pathology.
The trap is failing to recognize that chronic autoimmune damage is fundamentally a continuous, memory-driven secondary (anamnestic) immune response, which explains its high intensity and progressive nature.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Human Health and Disease - Class 12 |
| Concept | Primary vs Secondary Immune Response |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |