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Question #46507
The Question
A patient who recovered from a specific bacterial infection a year ago recently underwent a kidney transplant and is on a strict regimen of Cyclosporin A. If the patient is re-exposed to the same bacterial antigen, which of the following best describes the immunological consequence?
Options
- A.
The secondary immune response will be completely abolished because Cyclosporin A directly destroys pre-existing memory B-cells.
- B.
Antigen recognition by memory B-cells occurs, but the inhibition of T-helper cell activation prevents robust clonal expansion, severely dampening the anamnestic response.
- C.
The patient will mount a normal secondary humoral response because memory B-cells are entirely independent of T-cell cytokines for their activation.
- D.
Cell-mediated immunity will be suppressed, but the secondary humoral response will remain unaffected due to the direct activation of naive B-cells.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Memory B-cells|T-helper cells|Cyclosporin A
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often falsely compartmentalize Humoral (B-cell) and Cell-Mediated (T-cell) immunity as completely independent systems.
The trap lies in assuming that because memory B-cells already exist, they can mount a secondary response without T-helper cells.
This question tests the synthesis of NCERT facts regarding Cyclosporin A's function with the physiological interdependence of B and T lymphocytes during an anamnestic response.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Human Health and Disease - Class 12 |
| Concept | Primary vs Secondary Immune Response |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |