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Question #46341
The Question
An experimental drug specifically inhibits the Band 3 anion exchanger protein on the erythrocyte membrane. A subject administered this drug exhibits normal diaphragmatic contraction and pulmonary ventilation, yet rapidly develops severe tissue-level hypercapnia and hypoxia. Which of the following best explains the primary physiological bottleneck causing this condition?
Options
- A.
Accumulation of intracellular HCO3- in erythrocytes halts the forward reaction of carbonic anhydrase, preventing further CO2 diffusion from tissues.
- B.
Inhibition of the chloride shift directly prevents the binding of CO2 to the globin chain, drastically reducing carbaminohemoglobin formation.
- C.
The lack of Cl- influx prevents the dissociation of oxygen from oxyhemoglobin, completely neutralizing the Bohr effect at the tissue level.
- D.
The drug directly denatures the carbonic anhydrase enzyme, preventing the hydration of metabolic CO2 into carbonic acid.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
Diaphragm|Chloride_Shift|Hamburger_Phenomenon|Carbonic_Anhydrase
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Understanding the thermodynamic purpose of the Chloride shift.
Students often memorize the Hamburger phenomenon but fail to realize its role in removing the product (HCO3-) to prevent chemical equilibrium.
The trap lies in confusing mechanical ventilation (diaphragm) with the biochemical necessity of product clearance for continuous gas exchange.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Breathing and Exchange of Gases - Class 11 |
| Concept | Diaphragm Mechanics |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |