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Question #45880
The Question
Which of the following statements regarding cellular DNA replication and retroviral (HIV) multiplication is INCORRECT?
Options
- A.
In eukaryotic replication, the template strand with 5' → 3' polarity dictates discontinuous synthesis, forming Okazaki fragments.
- B.
HIV reverse transcriptase synthesizes a complementary DNA strand yielding an RNA-DNA hybrid, followed by the degradation of the RNA template.
- C.
The synthesis of the second viral DNA strand by reverse transcriptase involves a replication fork and the mandatory formation of Okazaki fragments.
- D.
Once the viral double-stranded DNA is integrated into the host macrophage genome, it directs the synthesis of viral RNA using host RNA polymerase.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Evolutionary_Exception
Tackle problems where standard rules evolve or change based on specific environmental constraints.
Concepts Behind This Question
HIV Replication Cycle|Reverse Transcriptase|Integrase
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often erroneously assume that all DNA synthesis universally involves replication forks and Okazaki fragments.
The trap relies on failing to distinguish between the simultaneous, bidirectional semi-conservative replication of a cellular dsDNA genome and the sequential, continuous synthesis of dsDNA from an ssRNA template by viral Reverse Transcriptase.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Molecular Basis of Inheritance - Class 12 |
| Concept | Okazaki Fragment Logic |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |