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Question #45823
The Question
In a eukaryotic chromosome, two linked genes, X and Y, are separated by a short physical distance that is highly enriched with microsatellite repeats. If the organism develops a deficiency in its mismatch repair (MMR) system, which of the following statements is INCORRECT regarding the genetic and molecular dynamics of this region?
Options
- A.
During replication, DNA polymerase is prone to slippage in this region, leading to repeat expansions or contractions due to the MMR deficiency.
- B.
The repetitive nature of the intervening sequence makes it a hotspot for unequal crossing over during the pachytene stage of meiosis I.
- C.
The calculated recombination frequency (RF) between genes X and Y will remain strictly proportional to their physical distance in base pairs.
- D.
The genetic map distance between X and Y will appear artificially inflated compared to euchromatic regions of the exact same physical length.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
DNA Polymerase Directionality|Recombination Frequency|Human Genome Repetitive DNA
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often rigidly apply Morgan's rule that 'Recombination frequency is directly proportional to physical distance' without realizing that recombination hotspots (like repetitive microsatellite DNA) distort this collinearity.
The trap tests the synthesis of DNA replication errors (slippage) and chromosomal mapping (linkage distortion).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Principles of Inheritance and Variation - Class 12 |
| Concept | Recombination Frequency (RF) |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |