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Question #45764
The Question
In an experiment, RNA interference (RNAi) is utilized to silence the expression of specific actin-binding proteins responsible for microfilament depolymerization in human macrophages. Which of the following represents the most accurate physiological consequence of this silencing?
Options
- A.
The macrophages will exhibit continuous amoeboid movement due to the permanent stabilization of the plasmasol state.
- B.
The transition from plasmagel to plasmasol will be inhibited, effectively arresting pseudopodia formation and phagocytic activity.
- C.
Ciliary movement will be completely halted as the 9+2 axonemal arrangement of microtubules is disrupted.
- D.
The macrophages will fail to produce and secrete immunoglobulins due to the arrest of cytoplasmic streaming.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Actin_Filaments|RNAi_Mechanism|Pseudopodia_Formation
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Understanding that cellular locomotion via pseudopodia requires 'dynamic instability'—both polymerization and depolymerization of actin.
A common misconception is that building the cytoskeleton (polymerization) alone drives movement, ignoring the necessity of the gel-to-sol transition.
The distractors also test functional overlap traps, such as confusing microfilaments with microtubules, and macrophage phagocytosis with B-cell antibody secretion.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Locomotion and Movement - Class 11 |
| Concept | Amoeboid Movement Mechanism |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |