Before You Begin
Question #45757
The Question
A somatic mutation in a proto-oncogene leads to an autonomous, hypersecreting tumor in the adrenal cortex, causing primary hyperaldosteronism. Regarding the patient's diuretic dynamics and systemic physiology, which of the following statements is INCORRECT?
Options
- A.
The patient will exhibit chronic hypertension due to unregulated conditional reabsorption of Na+ and water in the distal parts of the tubule.
- B.
The Juxtaglomerular (JG) cells will upregulate renin secretion in an attempt to correct the drastically altered Na+/K+ ionic balance.
- C.
The patient is at a high risk of cardiac arrhythmias due to the continuous, unregulated excretion of K+ into the filtrate.
- D.
The physiological negative feedback loop will result in significantly reduced levels of circulating Angiotensin II.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Diuretic Dynamics|Oncogenes vs Proto-oncogenes|RAAS Mechanism
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: The RAAS Negative Feedback Loop.
Students often memorize the RAAS pathway linearly (Renin -> Ang II -> Aldosterone) and assume that if Aldosterone is high, the entire system must be hyperactive.
They fail to distinguish between 'primary' hypersecretion (where an autonomous tumor suppresses upstream regulators like Renin) and 'secondary' hypersecretion (driven by high Renin).
Option B exploits this by offering a plausible-sounding but physiologically false compensatory mechanism.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Excretory Products and Their Elimination - Class 11 |
| Concept | Diuretic Dynamics |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |