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Question #45753
The Question
A patient with severe over-activation of the Renin-Angiotensin-Aldosterone System (RAAS) exhibits elevated blood pressure and a significantly increased Glomerular Filtration Rate (GFR). Despite having a normal fasting plasma glucose concentration of 95 mg/dL, trace amounts of glucose are consistently detected in their urine. Which of the following statements best explains this physiological anomaly?
Options
- A.
Angiotensin II directly downregulates the expression of Na+/glucose symporters (SGLT) in the proximal convoluted tubule.
- B.
The elevated GFR increases the filtered load of glucose, causing it to exceed the transport maximum (Tm) of the tubular carriers.
- C.
Aldosterone-induced hypernatremia competitively inhibits the secondary active transport of glucose in the nephron.
- D.
The renal threshold for glucose is an absolute value determined solely by plasma concentration, indicating a concurrent pancreatic defect.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
Aldosterone|Juxtaglomerular_Apparatus|Renal_Threshold
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often memorize the static fact that 'glucosuria only occurs when blood sugar exceeds 180 mg/dL' (the standard renal threshold).
This question tests the advanced NCERT-Plus concept that the renal threshold is not just a static plasma concentration, but a dynamic interplay between GFR and Plasma Concentration (Filtered Load).
High GFR can cause the filtered load to exceed the Transport Maximum (Tm) even at normal plasma glucose levels.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Excretory Products and Their Elimination - Class 11 |
| Concept | Renal Threshold Concept |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |