Before You Begin
Question #45750
The Question
In a patient suffering from autoimmune glomerulonephritis, the glomerular filtration barrier is severely compromised, leading to the leakage of large amounts of immunoglobulins into the filtrate. Subsequently, the patient develops an inability to properly excrete certain nitrogenous wastes and maintain blood pH, even before complete renal failure occurs. Which of the following best explains this secondary excretory impairment?
Options
- A.
The high concentration of antibodies in the filtrate competitively blocks the aldosterone-mediated active reabsorption of Na+ in the Distal Convoluted Tubule (DCT).
- B.
Protein overload overwhelms the reabsorptive capacity of the Proximal Convoluted Tubule (PCT), causing epithelial cell damage that impairs the active secretion of H+, K+, and ammonia.
- C.
The leaked immunoglobulins bind to and block the aquaporins in the collecting duct, preventing the passive secretion of urea into the medullary interstitium.
- D.
The autoimmune response shifts from humoral to cell-mediated, directly destroying the podocytes and thereby halting the tubular secretion of creatinine.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
Immunoglobulins|Glomerular_Filtration_Barrier|Active_vs_Passive_Immunity
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often view glomerular filtration and tubular secretion as completely independent processes.
The trap is assuming that glomerular damage only affects the Glomerular Filtration Rate (GFR).
This question requires the synthesis of NCERT facts to understand that a primary filtration failure (proteinuria) creates a downstream toxic effect on the PCT (protein overload), which subsequently destroys the tubule's capacity for active secretion.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Excretory Products and Their Elimination - Class 11 |
| Concept | Tubular Secretion Specificity |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |