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Question #45575
The Question
Regarding the pathogenesis of HIV and its progression from an asymptomatic infection (STI) to Acquired Immunodeficiency Syndrome (STD), which of the following statements is INCORRECT?
Options
- A.
The virus evades complete immune clearance by utilizing macrophages as a persistent viral factory, where viral DNA integrates into the host genome.
- B.
The transition from STI to STD is marked by a critical depletion of CD4+ Helper T-cells, which are destroyed during viral progeny release.
- C.
The failure to mount an effective active immune response against opportunistic infections is due to the direct viral destruction of both Cytotoxic T-cells and B-lymphocytes.
- D.
The presence of anti-HIV antibodies in the host's serum indicates an infection but fails to neutralize the intracellular viral reservoirs, allowing disease progression.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
STI_vs_STD_Distinction|Active_vs_Passive_Immunity
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Target Specificity vs.
Systemic Failure.
Students often confuse the overall failure of the immune system (which involves B-cells and Cytotoxic T-cells) with the direct cellular target of HIV.
The trap relies on the misconception that because humoral and cell-mediated immunity fail, the virus must be directly destroying the effector cells (B and Tc cells).
However, NCERT strictly specifies that HIV targets and destroys Helper T-cells (CD4+), causing an indirect, cascading collapse of the entire immune network.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Reproductive Health - Class 12 |
| Concept | STI vs STD Distinction |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |