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Question #45572
The Question
Intracytoplasmic Sperm Injection (ICSI) is an advanced ART procedure used primarily for severe male infertility. While highly successful, geneticists note a slightly elevated risk of chromosomal anomalies in the resulting offspring compared to natural conception. Which of the following best explains the fundamental biological basis for this risk?
Options
- A.
A. The micromanipulation needle frequently disrupts the secondary oocyte's meiotic spindle, directly inducing polyploidy in the zygote.
- B.
B. ICSI bypasses natural gamete competition and zona pellucida penetration, allowing sperm carrying paternally derived aneuploidy to achieve fertilization.
- C.
C. Direct injection prevents the cortical reaction, leading to a higher incidence of polyspermy and subsequent chromosomal imbalance.
- D.
D. The procedure alters Mendelian segregation during the zygote's first cleavage, increasing the frequency of non-disjunction.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Evolutionary_Exception
Tackle problems where standard rules evolve or change based on specific environmental constraints.
Concepts Behind This Question
ICSI Procedure|Aneuploidy vs Polyploidy|Mendelian Gamete Frequency
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Understanding the evolutionary purpose of fertilization barriers.
Students often view ICSI purely as a mechanical solution to infertility, missing the genetic implication that bypassing natural selection (motility/zona penetration) allows genetically compromised (aneuploid) gametes to fertilize.
The trap also tests the distinction between Aneuploidy (abnormal chromosome number) and Polyploidy (extra sets of chromosomes), and the timing of Mendelian segregation.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Reproductive Health - Class 12 |
| Concept | ICSI Procedure |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |