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Question #45570
The Question
During an Intra Cytoplasmic Sperm Injection (ICSI) procedure for severe male infertility, a sperm is mechanically injected directly into the ovum. Although syngamy is successful and a diploid zygote forms, the embryo arrests during early cleavage and fails to develop into a viable blastocyst. Assuming no gross chromosomal aneuploidy, which of the following best explains this specific developmental failure?
Options
- A.
Failure of the sperm to undergo capacitation and the acrosome reaction prior to penetrating the ovum.
- B.
Epigenetic anomalies from bypassing natural sperm selection, disrupting the transition from maternal to zygotic gene expression.
- C.
Non-extrusion of the second polar body due to the failure of the sperm to activate the Anaphase Promoting Complex (APC).
- D.
Premature dissolution of the zona pellucida during early cleavage, preventing the establishment of embryogeny directionality.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
ICSI Procedure|Differentiation of Stem Cells|Embryogeny Directionality
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often assume that successful fertilization in ART guarantees embryonic development.
The trap lies in distinguishing between the mechanical requirements for fertilization (which ICSI solves) and the molecular/epigenetic requirements for embryogeny (which ICSI can sometimes disrupt).
Options A and C are 'Common Half-Truths' that apply to natural fertilization failures but are negated by the premise of successful ICSI and syngamy.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Reproductive Health - Class 12 |
| Concept | ICSI Procedure |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |