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Question #45569
The Question
Intracytoplasmic Sperm Injection (ICSI) is an advanced Assisted Reproductive Technology (ART) that bypasses natural gamete selection barriers. Which of the following statements regarding the cellular and genetic implications of ICSI is INCORRECT?
Options
- A.
ICSI bypasses the natural selection mechanisms of the zona pellucida, thereby increasing the probability of transmitting paternal chromosomal anomalies to the offspring.
- B.
If the injected sperm carries an (n+1) chromosomal complement due to nondisjunction during Anaphase II, the resulting zygote will exhibit polyploidy.
- C.
If a sperm carrying both X and Y chromosomes due to Meiosis I nondisjunction is injected, the resulting zygote will manifest Klinefelter syndrome.
- D.
The female gamete utilized for the ICSI procedure is a secondary oocyte arrested at Metaphase II, which completes its final meiotic division only after the injection.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
ICSI Procedure|Spermatogenesis vs. Oogenesis Chronology|Down/Klinefelter/Turner Syndrome Karyotypes
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students frequently confuse 'Aneuploidy' (addition/deletion of a single chromosome, e.g., 2n+1) with 'Polyploidy' (addition of entire chromosome sets, e.g., 3n).
The question tests the integration of Reproductive Health (ICSI bypassing natural selection) with Principles of Inheritance (chromosomal disorders) while utilizing a strict micro-terminology trap.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Reproductive Health - Class 12 |
| Concept | ICSI Procedure |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |