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Question #45530
The Question
'Saheli' is a non-steroidal oral contraceptive pill developed by CDRI, Lucknow. Unlike traditional combined oral contraceptives, it does not cause widespread steroidal side effects such as premature bone loss. Which of the following best explains its precise molecular mechanism of action?
Options
- A.
It acts as an estrogen receptor antagonist in the endometrium, inhibiting the transcription of genes required for cellular proliferation, while maintaining bone density.
- B.
It inhibits the secretion of gonadotropins (FSH and LH) from the anterior pituitary via negative feedback, thereby preventing follicular development and ovulation.
- C.
It acts as a competitive progesterone receptor antagonist in the uterine wall, inducing premature endometrial desquamation and preventing implantation.
- D.
It functions as a systemic estrogen receptor antagonist, completely blocking estrogen-mediated mitotic division in both the uterine lining and osseous tissue.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
Endometrium|Estrogen Receptors|Cell Cycle
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often memorize the NCERT line that Saheli 'prevents implantation' but fail to distinguish its non-steroidal SERM mechanism from traditional steroidal pills (which inhibit ovulation) or antiprogestins.
The trap lies in assuming that an estrogen blocker must act systemically (Option D), which would detrimentally affect bone density, missing the evolutionary/pharmacological brilliance of tissue-selective modulation.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Reproductive Health - Class 12 |
| Concept | Saheli Pill Mechanism |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |