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Question #45512
The Question
During the normal menstrual cycle, the transition of the ruptured Graafian follicle into a functional corpus luteum requires granulosa cells to undergo luteinization. If a targeted mutation converts a proto-oncogene into an active oncogene within these granulosa cells just prior to ovulation, which of the following is the most likely physiological consequence?
Options
- A.
The granulosa cells will prematurely exit the cell cycle, leading to an oversized corpus luteum and hypersecretion of progesterone.
- B.
The granulosa cells will fail to arrest mitotic division, preventing functional differentiation into lutein cells and causing a deficiency in progesterone.
- C.
The follicle will immediately undergo atresia due to oncogene-induced apoptosis, triggering a sudden drop in estrogen levels.
- D.
Theca interna cells will undergo compensatory differentiation to secrete progesterone, maintaining the secretory phase of the endometrium.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Evolutionary_Exception
Tackle problems where standard rules evolve or change based on specific environmental constraints.
Concepts Behind This Question
Corpus Luteum|Oncogenes|Progesterone|Granulosa Cells
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: The inverse relationship between cellular proliferation (mitosis) and terminal differentiation (secretion).
Students often confuse 'tumor growth' (proliferation) with 'glandular hyperactivity' (differentiation).
The trap (Option A) exploits the misconception that an oncogene makes a gland 'hyperactive' in its secretory function, whereas it actually halts functional differentiation by trapping the cell in the mitotic cycle.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Human Reproduction - Class 12 |
| Concept | Corpus Luteum Fate |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |