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Question #45463
The Question
A rare autoimmune disorder is triggered by thymic hypoplasia, leading to a failure in the negative selection of T-lymphocytes. These self-reactive T-cells escape into circulation and specifically destroy the somatic cells within the seminiferous tubules that maintain the blood-testis barrier. Which of the following statements is INCORRECT regarding the organs, cells, and hormones involved in this pathogenesis?
Options
- A.
The targeted cells in the seminiferous tubules normally secrete factors essential for spermiogenesis and are stimulated by FSH.
- B.
The primary lymphoid organ responsible for this defect is a lobular structure located on the dorsal side of the heart and the aorta.
- C.
The peptide hormones deficient in this condition normally provide cell-mediated immunity and also promote the production of antibodies.
- D.
The destruction of the targeted testicular cells exposes the developing haploid spermatids to the immune system, exacerbating the autoimmune response.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Thymosin Specificity|Autoimmunity Principles|Sertoli Cell Functions
Why This Question Is Tricky
Common Mistakes
Location Trap & Functional Overlap: Students frequently misread anatomical positions in NCERT (Dorsal vs.
Ventral).
Furthermore, a common misconception is that thymosins ONLY affect cell-mediated immunity, leading students to incorrectly guess Option C as the false statement, forgetting the specific NCERT line stating that thymosins also promote antibody production.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Chemical Coordination and Integration - Class 11 |
| Concept | Thymosin Specificity |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |