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Question #45458
The Question
A patient suffering from severe chronic renal failure relocates to a high-altitude region (>3500 meters). Despite experiencing severe systemic hypoxic stress, the patient fails to exhibit the primary long-term physiological acclimatization response. Which of the following statements correctly identifies the missing mechanism and its consequence?
Options
- A.
Failure of juxtaglomerular cells to secrete the peptide hormone erythropoietin, preventing the compensatory increase in red blood cell production.
- B.
Inability of the pneumotaxic centre to detect low pO2, leading to a failure in increasing the pulmonary ventilation rate.
- C.
Hyper-secretion of renin by the compromised kidneys, which directly inhibits erythropoiesis in the red bone marrow.
- D.
Failure of the liver to synthesize sufficient erythropoietin, as it is the primary organ for its production during high-altitude hypoxic stress.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Erythropoietin|Feedback_Mechanism_Loops|Birth/Death_Rate_vs_Immigration/Emigration
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Integrating 'Organisms and Populations' (high-altitude acclimatization) with 'Chemical Coordination' (kidney as an endocrine organ).
Students often memorize that hypoxia automatically increases RBCs, failing to recognize that this feedback loop is entirely dependent on the structural integrity of the renal juxtaglomerular cells to produce EPO.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Chemical Coordination and Integration - Class 11 |
| Concept | Erythropoietin Function |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |