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Question #45438
The Question
A patient with chronic hypertension is treated with a pharmacological agent that specifically blocks the Angiotensin-Converting Enzyme (ACE). Which of the following ionic imbalances is most likely to occur as a direct consequence of this blockade, and what is the underlying physiological mechanism?
Options
- A.
Hyperkalemia; due to reduced aldosterone secretion leading to decreased K+ excretion in the distal tubules.
- B.
Hypokalemia; due to enhanced renin release causing excessive K+ secretion in the collecting duct.
- C.
Hypernatremia; due to the accumulation of Angiotensin I directly stimulating Na+ reabsorption.
- D.
Hyponatremia; due to a compensatory increase in Atrial Natriuretic Factor (ANF) secretion.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Angiotensin-Converting_Enzyme|Angiotensin_II|Vasoconstriction
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often memorize RAAS solely in the context of sodium retention and blood pressure elevation, neglecting the coupled nature of Na+/K+ exchange mediated by aldosterone.
The trap lies in failing to trace the upstream enzymatic blockade (ACE) to its downstream mineralocorticoid consequence (potassium retention).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Chemical Coordination and Integration - Class 11 |
| Concept | RAAS Mechanism |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |