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Question #45426
The Question
An experimental RNAi (RNA interference) vector is introduced into an animal model to specifically target the thyroglobulin transcripts in thyroid follicular cells. Assuming normal dietary iodine intake, all of the following physiological and molecular events will be observed in this animal EXCEPT:
Options
- A.
Continued uptake of inorganic iodide from the blood plasma by the thyroid follicular cells.
- B.
Arrest of T3 and T4 synthesis due to the absence of a tyrosine-rich glycoprotein scaffold.
- C.
Inhibition of thyroglobulin gene transcription in the nucleus by the RNA-induced silencing complex.
- D.
Elevated secretion of Thyroid Stimulating Hormone (TSH) from the anterior pituitary due to loss of negative feedback.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Thyroglobulin_mRNA|RNAi Vector Source|Translation_Mechanism
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students frequently confuse 'gene silencing' with 'transcriptional arrest'.
The trap relies on the NCERT Biotechnology distinction that RNAi is a post-transcriptional defense mechanism that prevents translation of mRNA, leaving the actual DNA transcription process intact.
It also tests the systemic understanding of endocrine bottlenecks and feedback loops.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Chemical Coordination and Integration - Class 11 |
| Concept | Thyroid Hormone Synthesis |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |