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Question #45409
The Question
In an organ transplant patient, a dual therapy of Cortisol and Cyclosporin A is administered to prevent graft rejection. Which of the following statements best describes the distinct cellular mechanisms by which these two agents induce immunosuppression?
Options
- A.
Cortisol interacts with intracellular receptors to regulate gene expression, while Cyclosporin A inhibits specific signal transduction pathways, preventing the activation of T-lymphocytes.
- B.
Cortisol generates second messengers like IP3 to suppress immunity, while Cyclosporin A binds to intracellular receptors to alter chromosome function.
- C.
Both agents synergistically bind to the same intracellular glucocorticoid receptor, amplifying the repression of immune-stimulating genes.
- D.
Cortisol inhibits T-cell activation by blocking membrane-bound receptors, while Cyclosporin A enters the nucleus to directly repress the transcription of inflammatory cytokines.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Cortisol|Glucocorticoid_Receptor|T-Cell_Activation
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Differentiating the mechanism of action of steroid hormones (intracellular receptors, genomic action) from peptide hormones (membrane receptors, second messengers) and understanding the distinct pharmacological target of Cyclosporin A (signal transduction in T-cells).
Students often fall for the 'Location Trap' by assigning second messengers to steroid hormones or assuming synergistic drugs share the exact same receptor.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Chemical Coordination and Integration - Class 11 |
| Concept | Hormone Receptors Location |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |