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Question #45402
The Question
A female patient with unexplained infertility tests positive for Anti-Sperm Antibodies (ASA) in her cervical mucus via ELISA. These antibodies bind to specific surface antigens on the sperm head. Which of the following physiological events is most directly inhibited by this immunological reaction, leading to fertilization failure?
Options
- A.
The influx of Ca2+ ions into the sperm, preventing the exocytosis of acrosomal enzymes.
- B.
The binding of the sperm to the ZP3 receptors located on the corona radiata cells.
- C.
The completion of the second meiotic division of the secondary oocyte prior to sperm contact.
- D.
The synthesis of hyaluronidase within the acrosome during capacitation in the female tract.
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Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Sperm Capacitation Location|ELISA Logic|Calcium Homeostasis
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: This question tests the exact cellular mechanism of the acrosome reaction (Ca2+ dependent exocytosis) while utilizing multiple high-yield NEET traps.
Option B uses a 'Location Trap' (ZP3 is on Zona Pellucida, not Corona Radiata).
Option C uses a 'Process Sequence Trap' (Meiosis II completes post-entry).
Option D uses a 'Timing/Location Trap' (Enzymes are synthesized during spermiogenesis, not capacitation).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Human Reproduction - Class 12 |
| Concept | Sperm Capacitation Location |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |