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Question #45373
The Question
In the seminiferous tubules, Sertoli cells form the Blood-Testis Barrier (BTB) via tight junctions and act as a metabolic 'reservoir' for developing germ cells. If a specific toxin disrupts these tight junctions without triggering an immediate autoimmune response, the developing spermatocytes still rapidly undergo apoptosis. Which of the following best explains the primary metabolic cause of this cell death?
Options
- A.
Spermatocytes lose access to Sertoli-derived lactate and cannot efficiently metabolize the newly influxed systemic blood glucose.
- B.
The sudden influx of systemic blood plasma dilutes the high concentration of fructose required for the survival of primary spermatocytes.
- C.
Leakage of Androgen Binding Protein (ABP) into the systemic circulation halts the glucose-to-glycogen conversion within the germ cells.
- D.
Exposure to high oxygen tension from the systemic blood directly inhibits mitochondrial oxidative phosphorylation in the developing spermatids.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Sertoli Cells|Lactate|Glucose|Blood-Testis Barrier
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students commonly memorize the Blood-Testis Barrier (BTB) solely as an immunological shield that prevents autoimmune destruction of haploid germ cells.
The trap lies in ignoring its critical role in 'metabolic isolation'.
The misconception is assuming all human cells directly utilize blood glucose for survival.
By testing the specific metabolic dependency (lactate vs. glucose) and ruling out the immune response in the question stem, it forces the student to understand the true 'nurse cell' biochemistry of Sertoli cells.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Human Reproduction - Class 12 |
| Concept | Sertoli Cell Functions |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |