Before You Begin
Question #45360
The Question
During oogenesis in a human female, a nondisjunction event occurs at Anaphase I, resulting in an aneuploid secondary oocyte. Assuming normal hypothalamic-pituitary function, which of the following is the most likely physiological outcome during that specific menstrual cycle?
Options
- A.
The Graafian follicle will undergo atresia prior to ovulation due to the activation of intra-ovarian meiotic checkpoints.
- B.
The LH surge will occur normally, but the resulting corpus luteum will secrete insufficient progesterone to maintain the endometrium.
- C.
The secretory phase of the endometrium will develop normally, as the follicular endocrine function is independent of the oocyte's karyotype.
- D.
The secondary oocyte will be ovulated but will fail to arrest at Metaphase II due to the abnormal chromosomal number.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Evolutionary_Exception
Tackle problems where standard rules evolve or change based on specific environmental constraints.
Concepts Behind This Question
Estrogen|Progesterone|Secondary_Oocyte|Polar_Body
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: Students often assume a 'quality control' mechanism exists where a genetically defective gamete halts the reproductive cycle.
The trap lies in failing to separate the endocrine function of the ovarian follicle (somatic cells) from the genetic maturation of the oocyte (germ cell).
The hormonal 'window of implantation' is entirely blind to the chromosomal integrity of the gamete.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Human Reproduction - Class 12 |
| Concept | Hormonal Feedback Loops |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |