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Question #45191
The Question
During periods of induced diapause or hibernation, extreme thermal stress can denature specific regulatory glycoproteins, disrupting the body's proteolytic balance. If the glycoprotein -1-antitrypsin (A1AT) fails to regulate neutrophil elastase due to such stress, the organism suffers from enzymatic auto-digestion of lung tissues. Which of the following statements is NOT correct regarding this physiological mechanism and its related concepts?
Options
- A.
The unchecked activity of neutrophil elastase leads to a decrease in the respiratory surface area, mimicking the chronic disorder emphysema.
- B.
-1-antitrypsin maintains homeostasis by directly repressing the transcription of the neutrophil elastase gene during metabolic shifts.
- C.
The failure of this regulatory protein under thermal stress leads to the degradation of alveolar walls despite the organism being in a dormant state.
- D.
Human protein -1-antitrypsin can be obtained for therapeutic use by introducing the specific coding DNA sequence into transgenic animals.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Alpha-1 Antitrypsin|Alien Species Invasion Impacts|Rivet Popper Hypothesis
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: The trap relies on confusing the 'Level of Biological Regulation'.
Students often memorize that A1AT 'stops' or 'regulates' elastase but fail to distinguish between transcriptional repression (gene expression) and direct enzymatic inhibition (protein-protein interaction).
This tests the micro-terminology of biochemical mechanisms.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Biotechnology and Its Applications - Class 12 |
| Concept | Alpha-1 Antitrypsin |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |