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Question #45152
The Question
An ecologist and a geneticist collaborate to explain Severe Combined Immunodeficiency (SCID) using Paul Ehrlich’s 'Rivet Popper Hypothesis.' They equate the patient's immune system to an airplane and the critical T and B lymphocytes to the 'rivets on the wings.' The loss of these 'rivets' leads to systemic immune collapse due to a specific enzyme deficiency. Regarding this enzyme and its genetic correction, which of the following statements is NOT correct?
Options
- A.
The missing 'rivet' function is linked to Adenosine Deaminase (ADA), an enzyme crucial for purine metabolism and lymphocyte survival.
- B.
Introducing functional ADA cDNA into the patient's cultured lymphocytes using a retroviral vector and returning them to the patient provides a permanent cure.
- C.
If the gene isolated from marrow cells producing ADA is introduced into cells at early embryonic stages, it could serve as a permanent cure.
- D.
While enzyme replacement therapy and bone marrow transplantation can temporarily restore the immune 'rivets,' they are not completely curative.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
ADA Deficiency|Bone Marrow Transplantation|Rivet Popper
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot: The trap exploits the distinction between a 'temporary treatment' and a 'permanent cure' in gene therapy.
Students frequently misread the NCERT text, assuming that the successful 1990 gene therapy using retroviral vectors on cultured lymphocytes was a permanent fix, failing to recall that lymphocytes have a finite lifespan and require periodic infusion unless corrected at the embryonic stage.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Biotechnology and Its Applications - Class 12 |
| Concept | Transgenic Animal Purpose |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |