Before You Begin
Question #45138
The Question
Gene therapy for Adenosine Deaminase (ADA) deficiency involves critical biological mechanisms and ethical boundaries. Read the following statements and select the INCORRECT statement:
Options
- A.
The standard therapy involves the ex-vivo transduction of the patient's lymphocytes with a functional ADA cDNA using a retroviral vector.
- B.
A permanent cure can be achieved if the functional ADA gene, isolated from early embryonic cells, is introduced into the patient's bone marrow cells.
- C.
If an in-vivo viral delivery method inadvertently transduces gonadal tissue, it bypasses somatic therapy and results in an ethically restricted heritable germline modification.
- D.
The genetically engineered lymphocytes infused into the patient are not immortal, necessitating periodic infusions of these cells to maintain immunity.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Adenosine_Deaminase|Retroviral_Vector|Germline_vs_Somatic
Why This Question Is Tricky
Common Mistakes
Conceptual Pivot & Word-Play Trap: Students often memorize the keywords 'marrow cells' and 'embryonic stages' from the NCERT text without cementing their exact roles (Source of the gene vs.
Target of the gene).
By swapping these terms, the question tests high-fidelity reading comprehension while simultaneously evaluating the student's understanding of why germline modifications (embryonic stages/gonadal tissue) are permanent and ethically restricted compared to somatic therapies.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Biotechnology and Its Applications - Class 12 |
| Concept | ADA Deficiency Genetic Correction |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |