Question #45062

Evaluate the following four statements regarding the reactivity of carbonyl compounds towards nucleophilic addition. Assign a value of 1 if the statement is True, and 0 if it is False.

$S_1$: The drastically lower rate of nucleophilic addition to di-tert-butyl ketone compared to formaldehyde is primarily because the electromeric polarization (E effect) of the \ce{C=O} $\pi$-bond is completely absent in hindered ketones. $S_2$: Acetophenone fails to form a crystalline bisulfite adduct with saturated aqueous \ce{NaHSO3} at 298 K primarily because severe steric crowding makes the formation of the $sp^3$ hybridized adduct highly unfavorable. $S_3$: The equilibrium constant ($K_{eq}$) for cyanohydrin formation is drastically lower for di-tert-butyl ketone than for acetone due to the severe steric strain (B-strain) between the bulky tert-butyl groups in the $sp^3$ hybridized product. $S_4$: Cyclohexanone forms a crystalline bisulfite adduct with aqueous \ce{NaHSO3} more readily than 3-pentanone, because the cyclic structure 'ties back' the alkyl chains, significantly reducing steric hindrance in the transition state.

Consider the truth values as a 4-bit binary number $S_1 S_2 S_3 S_4$. What is the decimal equivalent of this binary number?