Before You Begin
Question #133118
The Question
Given below are two statements: one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A): Recombinant therapeutics require rigorous downstream processing to completely eliminate host cell proteins before clinical formulation. Reason (R): Traces of host cell proteins can act as allergens, triggering an IgE-mediated anaphylactic response that negates the therapeutic efficacy of the biotechnological product.
In the light of the above statements, choose the most appropriate answer from the options given below:
Options
- A.
Both (A) and (R) are correct and (R) is the correct explanation of (A)
- B.
Both (A) and (R) are correct but (R) is not the correct explanation of (A)
- C.
(A) is correct but (R) is not correct
- D.
(A) is not correct but (R) is correct
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Comparative_Analysis
Sharpen your ability to evaluate multiple scenarios and distinguish between competing potential answers.
Concepts Behind This Question
Downstream Processing|Chromatography|Antigens
Why This Question Is Tricky
Examiner Levers
Logical Assertion
Tests the causal relationship between two true statements.
Difficulty Boost : +4Common Mistakes
Conceptual Pivot: Integrating Biotechnology (Downstream processing) with Immunology (Allergy/IgE).
Students often memorize downstream processing merely as 'separation and purification' for product concentration, failing to recognize the critical clinical imperative: removing immunogenic host cell impurities to prevent fatal anaphylactic responses.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Biotechnology : Principles and Processes - Class 12 |
| Concept | Downstream Processing |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |