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Question #131962
The Question
Given below are two statements: one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A): In the industrial production of Cyclosporin A, inadequate oxygen transfer in a sparged stirred-tank bioreactor compromises the clinical efficacy of the final product obtained after downstream processing. Reason (R): Sub-optimal oxygen and pH levels shift the metabolic flux of Trichoderma polysporum, leading to the synthesis of biologically inactive peptide isomers that are difficult to separate during purification.
In the light of the above statements, choose the most appropriate answer from the options given below:
Options
- A.
Both (A) and (R) are true and (R) is the correct explanation of (A)
- B.
Both (A) and (R) are true but (R) is not the correct explanation of (A)
- C.
(A) is true but (R) is false
- D.
(A) is false but (R) is true
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Trichoderma polysporum|Bioreactor|Downstream Processing
Why This Question Is Tricky
Examiner Levers
Logical Assertion
Tests the causal relationship between two true statements.
Difficulty Boost : +4Common Mistakes
Conceptual Pivot: Students often memorize that downstream processing involves 'separation and purification' but fail to connect it to upstream bioreactor conditions.
The trap lies in understanding that downstream processing cannot magically fix upstream metabolic errors (like the formation of structural isomers due to poor oxygenation).
It tests the synthesis of 'Microbes in Human Welfare' (Cyclosporin A source) with 'Biotechnology Principles' (Bioreactor geometry and Downstream Processing limits).
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Biotechnology : Principles and Processes - Class 12 |
| Concept | Downstream Processing |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |